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Best over counter medications - May 2025

Last Updated - May 2, 2025

1
Best Choice
11% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex
11% Off

Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicines, 2 x 6 Fl Oz

Mucinex

$19.97

$22.49
(11% Off)

More Details
Main highlights
- USAGE: Use as directed; For ages 12+ years
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust(1) and is also the #1 Pharmacist Recommended OTC Expectorant(2); Get the brand that doctors trust and recommend
- SORE THROAT RELIEF: Both liquids contain Acetaminophen, which helps reduce fever and relieves sore throat, headache, and body pain
- NIGHTTIME COLD AND FLU MEDICINE FOR ADULTS: Nighttime liquid contains Triprolidine HCl, an antihistamine, which helps relieve runny nose & sneezing
- NASAL DECONGESTANT: Both liquids contain Phenylephrine HCl, a nasal decongestant, which helps relieve stuffy nose, sinus pressure, & nasal congestion
- FSA & HSA Eligible: Save Up to 30%; Cover out-of-pocket expenses with pre-tax dollars (Product eligibility may vary by plan. Check with your benefits administrator to determine which expenses are eligible before you shop)
- COUGH MEDICINE FOR ADULTS: Both liquids contain Dextromethorphan HBr, which helps suppress and quiet cough
- COUGH COLD AND FLU MEDICINES FOR ADULTS: This combo pack of Maximum Strength Mucinex Fast-Max Cold & Flu and Nightshift Severe Cold & Flu provides powerful multi-symptom cold and flu relief for your worst cold and flu symptoms
- CHEST CONGESTION RELIEF: Daytime liquid contains Guaifenesin, an expectorant, which helps relieve chest congestion and thins and loosens mucus
- (1)IQVIA using ProVoice Survey, August 2023; (2)U.S. News & World Report/Pharmacy Times 2023-2024
$19.97
$22.49 (11% Off)
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Excedrin

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Excedrin

$19.73

More Details
Main highlights
- One bottle of 200 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
- Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier
- Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
- Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
- Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
$19.73
3
Best Value
24% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
- Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
- Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction
- Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
- 100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
$12.47
$16.59 (24% Off)
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Gas-X

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Gas-X

$10.48

More Details
Main highlights
- Simethicone 250 mg gas relief softgels are portable and easy to swallow
- One 30 count package of Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg; number 1 Anti-Gas Relief Brand
- HSA and FSA eligible product
- Gas-X simethicone softgels provide fast gas and bloating relief
- Gas-X is the number 1 doctor recommended OTC anti-gas product*
- Gas-X is the name you turn to when you need serious gas relief
- Gas-X antigas goes to work in minutes to provide bloating and gas relief, rescuing you from embarrassing situations and helping you get back to feeling like yourself
- Contains 250 mg of simethicone—the highest dose available in any over-the-counter antigas pills
- Adults and children 12 years of age and older may take one or two simethicone gas relief softgels as needed, not to exceed two softgels in 24 hours
$10.48
5
20% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Motrin
20% Off

Motrin IB Ibuprofen 200mg Tablets, Ibuprofen Pain & Fever Reliever for Headache, Backache, Muscular Aches, Menstrual Pain & Minor Arthritis Pain, Over-The-Counter NSAID Medicine, 225 ct

Motrin

$16.01

$20.24
(20% Off)

More Details
Main highlights
- Trusted Brand: With a long history of providing effective pain and fever relief to families, Motrin is a brand you can rely on; Motrin products can help you and your family feel better, and make the most of every day
- Powerful Pain Relief: Each Motrin IB tablet contains 200 mg of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, a pain relief medicine to help stop pain at its source and provide muscle pain relief and period cramps pain relief when it counts
- How to Take: Adults and children 12 years and older, take one tablet every 4 to 6 hours while symptoms persist; if pain or fever does not respond to one tablet, two tablets may be used; do not exceed 6 caplets in 24 hours unless directed by a doctor
- Fever Reducer and Pain Reliever: Motrin IB tablets temporarily reduce fever and offer pain relief due to the common cold, minor pain of arthritis, headache, backache, toothache and menstrual cramps
- Effective Pain Relief: One value-sized 225 count bottle of Motrin IB tablets with the NSAID ibuprofen pain reliever help provide effective pain relief from minor aches and pains
$16.01
$20.24 (20% Off)

Best over counter medications - May 2025

Mucinex Fast-Max Cold and Flu & Nightshift Severe Cold and Flu Medicine for Adults, Over-the-Counter Medication Combo Pack for Sore Throat Relief, Decongestant, Cough & Cold Medicines, 2 x 6 Fl Oz

Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Gas-X Maximum Strength Gas Relief Softgels with Simethicone 250 mg - 30 Count

Motrin IB Ibuprofen 200mg Tablets, Ibuprofen Pain & Fever Reliever for Headache, Backache, Muscular Aches, Menstrual Pain & Minor Arthritis Pain, Over-The-Counter NSAID Medicine, 225 ct

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