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Best digestive supplements - September 2025

Last Updated - September 22, 2025

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Metamucil

Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health*, heart health by lowering cholesterol†, and healthy blood sugar levels*.

Metamucil

$38.99

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Main highlights
- PSYLLIUM HUSK FIBER CAPSULES help support: digestive health*, heart health by lowering cholesterol, and healthy blood sugar levels*.
- PROMOTE DIGESTIVE HEALTH & REGULARITY*. Metamucil psyllium fiber capsules help trap and remove the waste*.
- MULTIPLE HEALTH BENEFITS* in daily fiber capsules. Metamucil is the only leading fiber brand made with psyllium husk fiber
- DAILY FIBER CAPSULES. Metamucil fiber capsules are designed for daily use. No spoon or mixing required!
- 1 IN 10 AMERICANS GET ENOUGH FIBER from diet alone. Help close your fiber gap by taking Metamucil fiber capsules daily.
- #1 DOCTOR RECOMMENDED fiber brand. Trusted for over 90 years.
- !
$38.99
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Pure Encapsulations

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Pure Encapsulations

$36.20

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Main highlights
- Supports Digestion: Facilitates the normal breakdown of proteins, peptides, polysaccharides and disaccharides; assists with dairy, fiber, and protein digestion*
- Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs
- Nutrient Absorption: Contains a mixture of vegetarian enzymes developed to support nutrient bioavailability and absorption; supports digestion*
- Digestive Enzymes: Offers a broad-spectrum combination of vegetarian digestive enzymes designed to provide optimal activity across a wide pH range
- Dairy Enzyme Blend: This vegetarian enzyme blend supports digestion of dairy, sugar, lactose, and certain complex carbs; supports relief from occasional gas or bloating
$36.20
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Zenwise Health

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 60 Count

Zenwise Health

$19.97

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Main highlights
- Proven Probiotics – Guaranteed to arrive alive and work within hours in the small intestine where 90% of nutrient absorption occurs, helping support overall digestive health.
- Plant-Based Formula – Pure vegetarian enzymes, including bromelain and papain, combined with prebiotic fiber nourish your microbiome while supporting healthy digestion and immune function. Take 1 capsule before your meal to experience digestive delight.
- Gas & Bloating Relief – Targeted enzymes, including bromelain and papaya, work with beneficial microflora to ease uncomfortable bloating, reduce gas, and soothe digestive discomfort naturally.
- Fast-Acting Enzymes – Featuring powerful enzymes like bromelain (from pineapple) and papain (from papaya), this blend starts working immediately to break down food up to 39% more completely, easing indigestion for rapid, noticeable relief.
- 3-in-1 Formula – A potent blend of lab-proven enzymes, including bromelain and papaya, clinically proven probiotics, and prebiotics work synergistically to break down proteins, fats, and carbs while restoring digestive flora balance for optimal nutrient absorption and digestion. This formula helps maintain digestive wellness and promotes regularity.
$19.97
4
Best Value
54% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

NOW Foods
54% Off

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

NOW Foods

$20.00

$43.99
(54% Off)

More Details
Main highlights
- SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
- Packaged in the USA by a family owned and operated company since 1968
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
- CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
- BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
$20.00
$43.99 (54% Off)
5
15% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Physician's CHOICE
15% Off

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

Physician's CHOICE

$19.97

$23.52
(15% Off)

More Details
Main highlights
- Science Backed - Our Digestive Enzyme Probiotics are crafted based on scientific research. We have partnered with expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
- Safety Assured Standard of Quality: Our Digestive Enzymes are 3rd-party tested for purity and potency. Each bottle is manufactured w/ love & care in the USA with strict quality control - using imported & domestic ingredients. No Refrigeration Needed
- Probiotics that Survive the Gut: Formulated with 3 soil-based probiotic strains - specifically selected due to their ability to survive the harsh gut environment. Along with Organic Prebiotics that fuel the growth of healthy bacteria in the gut.
- Dual Action Relief: Our powerful digestive enzymes aid with breaking down food while the prebiotics & probiotics promote digestive function in the gut. They work synergistically to provide relief from mealtime discomfort. One Month Supply
- Beat the Bloat & Say Goodbye to Meal Time Discomfort: 16 beneficial enzymes that digest proteins, carbs, fruits, veggies, beans, dairy, & fats to cover all diets. With SBO Probiotics & Prebiotics to aid digestion further - Your New Meal Time Hack! Same great product you love, with a new look. Packaging May Vary!
$19.97
$23.52 (15% Off)

Best digestive supplements - September 2025

Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health, heart health by lowering cholesterol†, and healthy blood sugar levels.

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 60 Count

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

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Best digestive supplements - September 2025

Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health*, heart health by lowering cholesterol†, and healthy blood sugar levels*.

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 60 Count

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

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Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ - Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

Physician's Choice Probiotics 60 Billion CFU - 10 Strains + Organic Prebiotics - Immune, Digestive & Gut Health - Supports Occasional Constipation, Diarrhea, Gas & Bloating - for Women & Men - 30ct

Nutricost Digestive Enzymes 620mg, 120 Capsules - Complete Digestive Enzyme Supplement

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

Digestive Enzymes - 800mg Blend of All 10 Most Essential Digestive and Pancreatic Enzymes (Amylase, Lipase, Bromelain, Lactase, Papain, Protease, Cellulase, Maltase, Invertase) by Double Wood

Nature's Bounty Lactobacillus Acidophilus Probiotic Supplement - Daily Probiotic for Women/Men Digestive Health, 100 Million Organisms, Vegetarian, 1 Serving per Day, 120 Tablets

Enzymedica Digest Spectrum, Digestive Enzymes for Multiple Food Intolerances, Offers Fast-Acting Gas & Bloating Relief, 30 Count

OLLY Probiotic + Prebiotic Gummy, Digestive Support and Gut Health, 500 Million CFUs, Fiber, Adult Chewable Supplement for Men and Women, Peach, 30 Day Supply - 30 Count

Designs for Health Digestzymes - Digestive Enzymes + Betaine Hydrochloride for Gas & Bloating Relief - Pepsin, Ox Bile, Lactase Enzyme & Lipase Enzymes for Digestion (60 Capsules)

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 45 Count

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Metamucil, Fiber Capsules, 3-in-1 Psyllium Husk Fiber, 300 Capsules, Daily Fiber Supplement, Help support digestive health, heart health by lowering cholesterol†, and healthy blood sugar levels.